Researchers turn back the clock on human embryonic stem cells
Left to proper: Photos of an early, three day-old human embryo, 5 day-old human embryo, a colony of the brand new 3i human ESC cells developed by the Zambidis laboratory, and a colony of a traditional human ESC, which is developmentally extra mature. Human ESC colonies are stained for nuclei (blue), the stem cell marker OCT4 (pink), and the stem cell marker TRA-1-8 1 (inexperienced). Credit score: Elias Zambidis and Yulian Zhao Johns Hopkins scientists report success in utilizing a cocktail of cell-signaling chemical compounds to additional wind again the organic clock of human embryonic stem cells (ESCs), giving the cells the identical flexibility researchers have prized in mice ESCs. The investigators say the flexibility to reset the stem cells' developmental clock to an earlier stage gives new alternatives to efficiently coax human stem cells into making any form of cell on demand to be ...