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Label-free and dynamic detection of stem cell adhesion makes use of the photonic crystal-enhanced microscope. Credit score: Yue Zhuo, College of Illinois Researchers from the College of Illinois at Urbana-Champaign have invented a novel live-cell imaging technique that would sometime assist biologists higher perceive how stem cells rework into specialised cells and the way ailments like most cancers unfold. The Photonic Crystal Enhanced Microscope (PCEM) is able to monitoring and quantitatively measuring cell adhesion, a vital course of concerned cell migration, cell differentiation, cell division, and cell demise. "Our method is vital as a result of there are usually not presently label-free and high-resolution imaging instruments that permit cell-surface interactions to be quantified and imaged dynamically, though these processes are basic to issues like wound therapeutic, tissue...

More than 80 percent of cancers have increased telomerase activity, and other medical conditions are also associated with decreased or abnormal telomerase function. The ability to increase or decrease telomerase activity has important implications for treating cancers in which insufficient numbers of blood cells are produced. When a person's bone marrow is unable to keep up with the need for healthy blood cells, bone marrow failure is triggered. Bone marrow failure affects about seven in 100,000 people annually. TSY-1 has been used in China for many years to treat aplastic anemia, a condition in which the body stops producing enough new blood cells and myelodysplastic syndrome or preleukemia; both are associated with telomerase abnormality. The five-year study, led b y UCLA Jonsso n Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY-1 to affect telomerase activity in cancer cells lines, including one known as HL-60, as well as normal peripheral b...

"We have confirmed what earlier studies indicated, and gained new knowledge about molecular characteristics of these neural stem cells," says Milos Pekny, professor at the Institute of Neuroscience and Physiology. Neural stem cells with the ability to form new neurons in the brain are normally present in the hippocampus (the part of the brain connected to learning and memory) and in the subventricular zone of the brain. However, in 8 of 14 patients in the study, neural stem cells were present outside these regions, namely in the epileptic brain tissue that was surgically removed. Over 50 operations of this kind are conducted in Sweden each year, of which about 20 in Gothenburg, with most patients becoming seizure-free or having significant reduction in seizure frequency. After an extensive investigation aiming at the precise localization of the epileptic focus, brain tissue that is damaged due to malformation, injury or other cause, is surgically removed. Good teamwo...